Progressive Supranuclear Palsy Therapeutics Pipeline to Develop More Drugs as Small Molecule

Dec 4, 2017

Published by P&S Market Research, PSP currently exhibits growing pipeline 14 drug candidates.

December 4, 2017 /MarketersMedia/ —

The study analyzed that PSP therapeutics pipeline comprises approximately 14 drug candidates in different stages of development.The exact cause of PSP is unknown, but it has been observed that PSP is the accumulation of abnormal deposits of the tau protein in nerve cells in the brain, and eventual toxicity in nerve cells in the brain stem. The appearance of deposits of the microtubule-associated tau protein termed ‘neurofibrillary tangles’ is a common feature of tauopathies and development of progressive supranuclear palsy.

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According to the research findings, most of the drug candidates in PSP therapeutics pipeline are being developed as small molecule agents. Also, majority of the pipeline drug candidates are being developed using the oral route of administration.

Many companies are more focused on developing their drug candidate’s as small molecule, since small molecule can easily pass through the blood brain barrier due to their low molecular weight and small size.

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In April 2017, Biogen Inc. entered into an exclusive worldwide license agreement with Bristol-Myers Squibb Company to develop and commercialize BMS-986168, a Phase II investigational medicine for the treatment of Alzheimer’s disease (AD) and PSP. Some of the key players developing drugs for the treatment of progressive supranuclear palsy include AbbVie Inc., Biogen Inc., Asceneuron SA, Alzprotect SAS and others.

PSP Therapeutics Pipeline Analysis

• By Phase
• By Molecule Type
• By Route of Administration
• By Company

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Many contenders chasing champion Knicks

LEBRON James went to Philadelphia. Giannis Antetokounmpo moved to Miami. Kawhi Leonard returned to Toronto. A dozen or so former All-Star selections, the majority of them being former All-NBA picks, changed addresses this offseason as well. And they’re all chasing the New York Knicks. The 81st season of NBA play starts on Tuesday (Wednesday in Manila) with a tripleheader, highlighted by James and the 76ers heading to New York to face Jalen Brunson and the champion Knicks. They’ll get their championship rings before the game, see a banner swaying from the ceiling of Madison Square Garden and then get down to the task of doing something that nobody in the NBA has done for nearly a decade — repeat as title winners. The Knicks became the NBA’s eighth different champion in the last eight years, a run unprecedented in league history. They’re not the favorites to win the title this season; that role is shared by Victor Wembanyama’s San Antonio Spurs and Shai Gilgeous-Alexander’s Oklahoma City Thunder. But the Knicks weren’t expected to win it all last season either, and NBA Finals Most Valuable Player (MVP) Jalen Brunson points to the title as proof that words don’t have to matter. “There’s only potential distractions when you read and believe what people are saying,” Brunson said. “So, no matter what’s being said and no matter what’s been talked about, consistently or not, you believe what you want to believe, you hear what you want to hear. It’s on us as teammates, and individuals and professionals to understand what the nature of it is. ... The way we won was just because of how connected we were as a group. We’ve got to keep that.” There is no shortage of legitimate contenders, on both sides of the league. In the Eastern Conference, four of the last eight NBA Finals MVPs changed uniforms — Leonard returning to Toronto, Antetokounmpo going to Miami, and James and Jaylen Brown joining the Sixers. Detroit and Cleveland brought their rosters back virtually intact, as did the Knicks. Boston will plug Paul George into the hole created by Brown moving to Philadelphia and pair him with Jayson Tatum. Indiana gets Tyrese Haliburton back for the first time since losing Game 7 of the 2025 NBA Finals and expects to contend again. “From a team perspective, we don’t have any conversations about anything but winning a championship. That’s our goal. There’s nothing more to talk about,” Haliburton said. “There are no small wins. To me, the year’s successful if you win a championship. If not, it’s not.” And the Western Conference, as always, is loaded. Wembenyama and Gilgeous-Alexander are two of the game’s biggest stars, and the Spurs and Thunder lead the West pack. Nikola Jokic, always considered a serious contender for MVP honors, will try to get Denver back into title contention. Golden State still has Stephen Curry, the Los Angeles Lakers still have Luka Doncic, Houston is expected to contend with Kevin Durant leading the way, Portland finally will have Damian Lillard in uniform and Minnesota put together what’s expected to be an elite backcourt by pairing LaMelo Ball with Anthony Edwards. “New beginnings,” Ball said. “It’s literally a new story. We’re all excited here. It’s going to be fun.” The Spurs got to the NBA Finals last season after winning a Game 7 in Oklahoma City (OKC), ending hopes the Thunder had of being the league’s first back-to-back champion since the Warriors did it in 2017 and 2018. That loss, for certain, stung the Thunder. But the offseason in OKC was about getting ready for 29 opponents, not just the one in San Antonio. “We need to make sure that what we are doing is broad enough that it gives us a chance to be competitive across opponents, including ones that we are not aware that are going to be really good teams. That happens every single year,” Thunder coach Mark Daigneault said. “And so we need to be laser-focused on ourselves. We need to take the lessons from that series, for sure, and we did. But it’s certainly not something that we overcorrect for because you end up chasing your shadow, and it prevents you from being your best as you move forward.” There are six new coaches this season: Dusty May took his NCAA title won last spring with Michigan and moved to Dallas, Micah Nori takes over in Portland, Tiago Splitter will coach Chicago, Taylor Jenkins was tabbed to oversee the post-Giannis rebuild in Milwaukee, Sean Sweeney got the job in Orlando to replace Jamahl Mosley and Mosley will coach New Orleans. The NBA Cup final will move from Las Vegas to Indianapolis this year, the All-Star weekend is in Phoenix and there’s a No. 1 draft pick in AJ Dybantsa, who already is turning heads in Washington. But all eyes will eventually turn to June, and whoever will be the next team to hoist the Larry O’Brien Trophy.“We did something great last year,” Knicks wing Mikal Bridges said. “That was last year. I think the biggest thing coming into this year is that we know what it takes.”

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Reese lifts Dream past Valkyries to level WNBA finals

Oct 20, 2026

49ers beat Commanders to remain perfect in NFL

SAN FRANCISCO, California — The San Francisco 49ers had appeared to be strolling toward a routine win after quarterback Brock Purdy found tight end George Kittle in the endzone to cap a nine-play 64-yard drive in the first quarter. Washington responded with a 51-yard field goal from Drew Stevens but San Francisco were soon leading by 10 points after McCaffrey rushed from the one-yard line to make it 13-3. Another close-range McCaffrey touchdown in the second quarter after a 14-play 69-yard drive took San Francisco into a 20-3 lead at half-time. A 33-yard field goal from Eddy Pineiro made it 23-3 to the 49ers early in the third quarter and seemingly on course for a comfortable victory. Washington though began fighting back late in the third quarter with Daniels hitting Stefon Diggs for a touchdown to make it 23-10. Daniels tossed a second touchdown midway through the fourth quarter when he found Rachaad White to help take the score to 23-17. The Washington defense forced San Francisco to punt twice on their next two possessions and that left the Commanders one last chance to snatch a winning score. That drive ended with Daniels sacked at the Washington 42-yard line to end the game. AFP LISBON — Cristiano Ronaldo has been handed a 30-day suspension for leaving the Portuguese national team camp, the country’s football federation (FPF) announced on Monday (Tuesday in Manila). The 41-year-old abruptly left the Portugal camp on Sept. 30 during the UEFA Nations League, before accusing coach Jorge Jesus of breaking his word about giving him game time. Ronaldo apologized to supporters earlier in October, adding he would accept any punishment that was imposed. The former Manchester United and Real Madrid star, who will also have to pay a fine of 255 euros ($286), has received the minimum penalty provided for in the federation’s regulations, which stipulate suspensions of between one and six months for leaving the national team. Ronaldo left Portugal’s squad after first being made to warm up as a substitute against Norway on Sept. 27 and not being brought on, and then finding out he would not start against Denmark in the match on Oct. 1. Ronaldo’s suspension takes effect from the day of the Denmark match, meaning he has already served 19 days of his ban and will complete it by the end of October. The FPF disciplinary committee said it took into account “the remorse shown in the statement” issued by Ronaldo on Oct. 6, in which he admitted his mistake and expressed his willingness to accept a punishment. The five-time Ballon d’Or winner is Portugal’s all-time top goal scorer and record appearance-maker in men’s international football. But in his absence, Portugal won all four of their Nations League matches and qualified for the quarterfinals with two games to spare.

Oct 20, 2026

Ronaldo handed 30-day suspension

LISBON — Cristiano Ronaldo has been handed a 30-day suspension for leaving the Portuguese national team camp, the country’s football federation (FPF) announced on Monday (Tuesday in Manila). The 41-year-old abruptly left the Portugal camp on Sept. 30 during the UEFA Nations League, before accusing coach Jorge Jesus of breaking his word about giving him game time. Ronaldo apologized to supporters earlier in October, adding he would accept any punishment that was imposed. The former Manchester United and Real Madrid star, who will also have to pay a fine of 255 euros ($286), has received the minimum penalty provided for in the federation’s regulations, which stipulate suspensions of between one and six months for leaving the national team. Ronaldo left Portugal’s squad after first being made to warm up as a substitute against Norway on Sept. 27 and not being brought on, and then finding out he would not start against Denmark in the match on Oct. 1. Ronaldo’s suspension takes effect from the day of the Denmark match, meaning he has already served 19 days of his ban and will complete it by the end of October. The FPF disciplinary committee said it took into account “the remorse shown in the statement” issued by Ronaldo on Oct. 6, in which he admitted his mistake and expressed his willingness to accept a punishment. The five-time Ballon d’Or winner is Portugal’s all-time top goal scorer and record appearance-maker in men’s international football. But in his absence, Portugal won all four of their Nations League matches and qualified for the quarterfinals with two games to spare. Portugal host Denmark on Nov. 14 and then travel to face Wales on Nov. 17 in their final two Nations League Group A4 matches — by which time Ronaldo will have served his suspension. In a social media post shortly after his walk-out, Ronaldo accused Portugal boss Jesus of breaking his word about giving him game time in Nations League matches but insisted he was not retiring from international duty. “I will be available, as I have always been until today, to compete and win for our national team,” Ronaldo posted. He said Jesus had gone back on his word about bringing him on against Norway, and then in a press conference before the Denmark match had not said a series of points they had agreed upon during a conversation beforehand. One of Ronaldo’s preapproved talking points was that Jesus had “made a mistake in asking someone of the stature of Pele or Maradona to warm up and then not sending him on in the match.” Jesus, speaking several days later, said he would select Ronaldo for international duty if the forward was playing for his club Al Nassr, and was interested in being called up. Following the FPF’s announcement, Ronaldo did not directly react to the news on Instagram but did post a picture of himself preparing to train with his Saudi club, accompanied with the caption, “Putting in the work.” AFP